The AFC East-leading Buffalo Bills (8-3) are out west to take on the San Francisco 49ers (5-6) in the second game of what has become a Monday doubleheader. Below, we’ll look at the top-5 prop bet predictions for the Bills-49ers Monday Night Football matchup.

Due to COVID-19 regulations in Santa Clara, Calif., the game will be played at the Niners’ new temporary home of State Farm Stadium in Glendale, Ariz. Kickoff is set for 8:15 p.m. ET.

Also see:Bills vs. 49ers odds, picks and prediction

The 49ers opened at +2.5 and the current line is SF -2. The Bills are ranked #10 th in offense and 19 th in defense and the 49ers are ranked #20 th in offense and 11 th in defense. Vegas has been overvaluing the Bills and been expecting too much from the 49ers lately. After crunching 135 data points, CaptainObvious's predicted score is Bills 20. Buffalo is 14-7 to the over on the road. San Francisco is 4-2 straight up when hosting the Bills. Buffalo Bills vs San Francisco 49ers Prediction. Best Bet: Buffalo Bills -2.5. In this situation the Bills have the edge at quarterback. San Francisco’s entire environment has been disrupted and the 49ers still have severe injury problems. Prediction: Bills 27, 49ers 23 CBS Sports - Pete Prisco This game will be played at the Cardinals stadium because of Covid issues, which means it's the second time Buffalo will have played in the.

Bills vs. 49ers Week 13 MNF prop bet predictions

Odds via BetMGM; access USA TODAY Sports’ betting odds for a full list. Lines last updated at 1:10 p.m. ET.

Bills QB Josh Allen UNDER 267.5 passing yards (-110)

Allen ranks eighth with an average of 275.3 passing yards per game and has thrown for at least 284 in seven of 11 contests this season.

The Bills’ aerial blitz has slowed down of late, however, with Allen throwing for 263 or fewer yards in four of his last seven outings.

Now, he faces a San Francisco defense surrendering only 217.6 yards per game to opposing QBs — the second-lowest such figure in the league. Only two quarterbacks — Ryan Fitzpatrick with 350 yards in Week 5 and Aaron Rodgers with 305 in Week 9 — have eclipsed 268 yards vs. the Niners this season.

That make this a lean toward the UNDER 267.5 (-110).

Allen OVER 29.5 rushing yards (-121)

Allen has been one of the league’s top QB rushing threats since entering the league in 2018. He has rushed for 30 yards or more in 21 of 40 career games, including one postseason contest and five of 11 games this season.

That’s a bad matchup for a 49ers defense which has surrendered the most rushing yards (341, for an average of 31 per game) to opposing quarterbacks.

Go with the averages and the OVER 29.5 (-121).

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49ers RB Raheem Mostert OVER 53.5 rushing yards (-115)

Injuries have limited Mostert, the Niners’ leading rusher, to five games this season, but he’s still averaging a healthy 69.2 yards per contest and 5.2 yards per attempt. He has rushed for 56 or more yards in seven of his last eight games, including three in the 2019 playoffs, since taking over the team’s lead role in Week 12 of last season.

The Bills, meanwhile, entered the weekend allowing the seventh most rushing yards per outing (104.3) to opposing running backs.

With backup QB Nick Mullens at the helm, look for the Niners to rely on the run game, and look for Mostert to hit the OVER 53.5 (-115).

49ers TE Jordan Reed OVER 33.5 receiving yards (-115)

Whether it has been the now-injured George Kittle, Ross Dwelley or Reed, a San Francisco tight end has had 39 or more receiving yards in 10 of 11 games this season in head coach Kyle Shanahan’s TE-friendly scheme.

Reed has done it twice despite lingering injury issues which have limited him to six games this season.

A now healthy Reed figures to get plenty of looks against a Buffalo defense which surrenders the most catches (6.0) and the second-most yards (64.5) on average to opposing tight ends. Dwelley also is still in the San Fran TE mix, but Reed is the more accomplished and athletic option. We’ll go with the OVER 33.5 (-115) in a juicy matchup.

Worth a (long) shot: Reed to score TD and 49ers to win (+400)

In a total tossup game, why not take a shot at quadrupling your money by parlaying two very plausible outcomes?

Want some action on this game? Place a bet at BetMGM now. For more sports betting tips and advice, visit SportsbookWire.com. Please gamble responsibly.

Also see:

Allen used digital mapping to improve mechanics (Bills Wire)San Francisco got a lot of help in Week 13’s Sunday games (Niners Wire)

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Bills 49ers Prediction Stat Salt

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The Buffalo Bills (8-3) are against the San Francisco 49ers (5-6) on Monday, December 7. The over/under is set at for the outing.

The betting insights in this article reflect betting data from DraftKings as of December 1, 2020, 1:41 AM ET. See table below for current betting odds and CLICK HERE to bet at DraftKings Sportsbook.

Betting Information

Bills 49ers Prediction Super Bowl

Bills vs. 49ers props

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Total Facts

• Bills games have gone over 48 points on six occasions this season (54.5% of matchups).
• San Francisco’s contests have gone over 48 points on three occasions (27.3% of games).
• The total for this matchup is 48 points, 2.9 fewer than the combined scoring average of the two teams.
• These two teams allow a combined 48.7 points per game, 0.7 higher than the total for this matchup.
• The points total average for Bills games this season is 52.8, 4.8 points higher than the over/under for this matchup.
• Games involving the 49ers this year have averaged 46.8 points per game, a 1.2-point differential when compared to the over/under for this contest.
• The Bills are the 10th-highest scoring team in the league this year. The 49ers have scored the 20th-most points.
• San Francisco has surrendered the 11th-fewest points in NFL play this season, while Buffalo has given up the 18th-fewest.

Bills Betting Insights

• Buffalo’s games have hit the over in eight out of 11 outings this season (72.7%).
• Buffalo is 6-5 against the spread.
• The Bills are 3-4 ATS when playing as at least 2.5-point favorites.

49ers Betting Insights

• San Francisco has compiled a 5-6 record against the spread this season.
• The 49ers are 2-3 ATS when an underdog by at least 2.5 points.
• Five of San Francisco’s 11 games this year have gone over the point total (45.5% of its opportunities).

When the Bills Have the Ball

• The Bills, on average, score 4.1 more points per game this season (27.2) than the 49ers allow (23.1).
• When they meet or exceed their scoring average this season, Buffalo is 4-1 and 4-1 against the spread.
• When the San Francisco defense allows 23.1 points or fewer this year, the 49ers have put together a 5-0 overall record and a 5-0 record against the spread.
• The 49ers defense has given up an average of 315.2 yards per game so far this season, 57.3 yards fewer than the 372.5-yard average from the Bills offense.
• On average, the Bills pick up 5.9 yards per play and the 49ers give up 5.2.
• When the Buffalo offense puts together a game with at least their average in yardage, they are 5-0 overall and 3-2 against the spread this season.
• When San Francisco allows fewer total yards to opposing offenses than their season average, they are 5-2 against the spread and 5-2 overall this season.
• The Bills have averaged 104.2 yards per game on the ground this season, just 4.5 yards fewer than the 49ers have allowed to opposing rushing attacks (108.7).
• In games where the Buffalo rushing attack runs for at least their season average, the Bills are 4-0 overall and 1-3 against the spread.
• This season, when the San Francisco defense allows opponents to pick up less than 108.7 yards on the ground, they are 3-3 against the spread and 3-3 overall.
• This season, the 49ers have forced an average of 1.5 turnovers per game, equal to the 1.5 times Bills have turned the football over in each contest.
• When Buffalo turns the football over 1.5 times or fewer this season, they are 5-1 overall and 2-4 against the spread.
• San Francisco’s record this season when they force more than 1.5 turnovers: 3-1 ATS, 3-1 overall

When the 49ers Have the Ball

• The 49ers rack up 23.7 points per game, comparable to the 25.6 per contest the Bills give up.
• San Francisco is 4-1 against the spread and 4-1 overall a season ago when the team records at least 23.7 points.
• This season, Buffalo has a 4-1 record against the spread and a 4-1 record overall in games when it holds opponents to 27.2 or fewer points.
• The 49ers rack up 9.8 fewer yards per game (363.2), than the Bills allow per matchup (373). On average, the 49ers pick up 5.6 yards per play, while the Bills give up 5.7 per play.
• Buffalo has a 2-3 record ATS and a 4-1 record overall when holding its opponents to 373 yards or less.
• This season, the 49ers rack up 112.3 yards per game on the ground, 17.2 fewer per game than the Bills allow per outing (129.5).
• When San Francisco runs for at least 112.3 yards, it recorded a 4-3 ATS record and a 4-3 overall record.
• This season, Buffalo is 4-2 against the spread and 6-0 overall when holding opponents to no more than 129.5 rushing yards.
• This year, the 49ers turn the ball over 1.8 times per game, 0.3 more turnovers per game than the 1.5 the Bills force on average.
• San Francisco has a 3-1 record against the spread and a 3-1 record overall when it turns the ball over 1.8 times or less.
• When it forces 1.5 or more turnovers, Buffalo has a 5-1 record against the spread and a 5-1 record overall.

Bills Players to Watch

• Josh Allen leads the team with 3,030 passing yards (275.5 yards per game) and has a 68.8% completion percentage this year (267-of-388) while throwing 22 touchdowns and eight interceptions. He also has 310 rushing yards on 81 carries with six touchdowns, averaging 28.2 yards per game.
• Devin Singletary has rushed for 482 yards on 110 carries (43.8 yards per game) while scoring one touchdown. He also averages 18.8 receiving yards per game, grabbing 28 passes for 207 yards.
• This season, Stefon Diggs has 80 catches (on 111 targets) to lead the team with 945 yards (85.9 per game) while scoring four touchdowns.
• Cole Beasley has added 667 yards on 57 catches with three touchdowns. He has been targeted 71 times and puts up 60.6 receiving yards per game.
• In his rookie season, Gabriel Davis has caught 22 passes on 35 targets for 354 yards and four touchdowns, averaging 32.2 receiving yards per game.
• A.J. Klein has five sacks to lead the team, and has also added five TFL and 58 tackles this year.
• Jordan Poyer’s 90 tackles, four TFL, two sacks, and two interceptions make him the team-leader for tackles and interceptions.

49ers Players to Watch

• This year, Nick Mullens has collected 1,642 passing yards (234.6 yards per game) while going 139-for-206 (67.5% completion percentage) and throwing six touchdowns and seven interceptions in seven games.
• Raheem Mostert has churned out 346 rushing yards (69.2 yards per game) and two touchdowns in five games. He has tacked on 13 catches for 150 yards (30 receiving yards per game) with one receiving touchdown.
• Jerick McKinnon has 315 yards on 80 carries (28.6 ypg), with five rushing touchdowns. He also has 27 catches for 197 yards (17.9 ypg) and one touchdown.
• This season, Kendrick Bourne has 32 catches (on 50 targets) to lead the team with 412 yards (37.5 per game) while scoring one touchdown.
• Deebo Samuel’s statline this year shows 27 catches for 318 yards and one touchdown over the course of six games. He averages 53 receiving yards per game and has been targeted 35 times.
• Richie James Jr. has totaled 239 yards on 13 passes with one touchdown in 2020, averaging 47.8 yards per game on 19 targets in five contests.
• Kerry Hyder has collected a team-leading 7.5 sacks, while adding seven TFL and 36 tackles .
• This season, Fred Warner has totaled 87 tackles, three TFL, and two interceptions.
• Jamar Taylor has a two interceptions, 22 tackles, two TFL, one sack, and three passes defended this season.

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